These names in the original are "Zeus" and "Hermes," which were the same "gods" to the Greeks as Jupiter and Mercury to the Romans. There was a local legend in the region that these two gods had once appeared there as men and brought blessing. Paul's miraculous healing of the life-long crippled man encouraged the Lystron pagans to hope the gods had returned.

Source:

KJV Defenders Study Bible, by Dr. Henry Morris, Ph.D.
Publisher: Thomas Nelson
Language: English
DEF 10 ISBN 0-529-10444-x
DEF 10-1 ISBN 0-529-10445-8